Inhibition of Senescence Through Decreasing P16ink4a Expression by Sirt-1 in ADMA Exposed EPC
نویسندگان
چکیده
منابع مشابه
p16INK4a in cellular senescence
senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in H3K27me3 [2]. Upon senescence triggers, PRCs are displaced and the repressive H3K27me3 mark is removed...
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ژورنال
عنوان ژورنال: Advances in economics, business and management research
سال: 2023
ISSN: ['2352-5428']
DOI: https://doi.org/10.2991/978-94-6463-140-1_49